FAZAKERLEY LAB

We are interested in understanding how cells respond to hormonal cues to regulate metabolism, and how these processes are altered in disease. Our research focuses on the molecular mechanisms underlying cellular signalling, protein trafficking and subcellular organisation, and how these processes coordinate metabolic function in adipose and muscle tissue.

We are particularly interested in how signalling pathways regulate the localisation and activity of proteins to control cellular responses. For example, insulin stimulates the translocation of the glucose transporter GLUT4 to the plasma membrane, promoting glucose uptake. Understanding the molecular mechanisms that govern such processes provides insight into how cells coordinate metabolic responses and how their dysregulation contributes to metabolic disease.

Using advanced cell biology, proteomic and molecular approaches, we aim to uncover the molecular mechanisms that regulate cellular metabolism and understand how their disruption contributes to metabolic disease.