FAZAKERLEY LAB

We are interested in understanding how hormonal cues regulate glucose transport and cellular metabolism in adipose and muscle cells, and how these processes break down in disease.

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Hormones such as insulin play a central role in maintaining blood glucose homeostasis by stimulating glucose transport into adipose and muscle tissue. Insulin activates a signal transduction cascade in these tissues to promote the translocation of the glucose transporter GLUT4 from specialised intracellular storage vesicles to the plasma membrane, facilitating glucose uptake. We currently have an incomplete understanding of the signalling events and trafficking processes that control the redistribution of GLUT4. One of the objectives of our work is to fill in these knowledge gaps.

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In parallel, we explore broader questions surrounding signal transduction, protein localisation, and metabolic adaptation using advanced cell biology approaches.