Journal of Biological Chemistry (2026)

A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells

Danièle Stalder, Conceição Pereira, Dick JH van den Boomen, Petia Adarska, Dilip Menon, Daniel J Fazakerley, Francesca Bottanelli, Paul J Lehner, David C Gershlick

Nature Communicat-ions (2026)

Dynamic subcellular proteomics identifies regulators of adipocyte insulin action

Olivia J Conway, Josie A Christopher, Lisa M Breckels, Hanqi Li, Dilip Menon, Meghna Birla, Bethan L Hawkins, Lu Liang, Satish Patel, Francoise Koumanov, David C Gershlick, David B Savage, Michael P Weekes, Kathryn S Lilley, Daniel J Fazakerley

Journal of Biological Chemistry (2026)

Integrated analysis of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters

Yiju Zhang, Kristen C Cooke, Jonathan Scavuzzo, Harry B Cutler, Søren Madsen, Alison L Kearney, Olivia J Conway, Bethan L Hawkins, Dilip Menon, Sean J Humphrey, Françoise Koumanov, Jacqueline Stöckli, Thomas A Geddes, Daniel J Fazakerley, Alexis Diaz-Vegas, James G Burchfield, David E James

Stem Cell Reports (2026)

Adjusting PSC culture for neural organoid generation

Magdalena A Sutcliffe, Pia Jensen, Joycelyn Tan, Charles AJ Morris, Daniel J Fazakerley, Martin R Larsen, Madeline A Lancaster

American Journal of Physiology-Heart and Circulatory Physiology (2025)

Loss of RET-ROS at complex I induces diastolic dysfunction in mice that is reversed by aerobic exercise

Ana Vujic, Amy Koo, Guillaume Bidault, Jan Lj Miljkovic, Andrew M James, Andreas Dannhorn, Xiaowen Duan, Lucy M Davis, Jiro Abe, Joyce Valadares, Jordan J Lee, Alexis Diaz-Vegas, Keira Turner, Richard Goodwin, Daniel J Fazakerley, Antonio Vidal-Puig, Michael P Murphy, Thomas Krieg

Cell Metabolism
(2025)

Seeing the world through the eyes of cultured cells

Joycelyn Tan, Guy B Kunzmann, Sam Virtue, Jason R Cantor, Daniel J Fazakerley

PLOS One (2024)

Loss of Mfn1 but not Mfn2 enhances adipogenesis

Jake P Mann, Luis Carlos Tábara, Satish Patel, Pushpa Pushpa, Anna Alvarez-Guaita, Liang Dong, Afreen Haider, Koini Lim, Panna Tandon, Fabio Scurria, James EN Minchin, Stephen O’Rahilly S, Daniel J Fazakerley, Julien Prudent, Robert K Semple, David B Savage

Cold Spring Harbor Laboratory (2024)

Optimizing PSC culture for generating neural organoids​

Magdalena A Sutcliffe, Pia Jensen, Joycelyn Tan, Charles AJ Morris, Daniel Fazakerley, Martin R Larsen, Madeline A Lancaster

Molecular Metabolism (2024)

​Picalm, a novel regulator of GLUT4-trafficking in adipose tissue

Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J Fazakerley, Heike Vogel

Journal of Biological Chemistry (2024)

​A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

Harry JM Baird, Amber S Shun-Shion, Edson Mendes De Oliveira, Danièle Stalder, Lu Liang, Jessica Eden, Joseph E Chambers, I Sadaf Farooqi, David C Gershlick, Daniel J Fazakerley

The EMBO Journal (2024)

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

Joycelyn Tan, Sam Virtue, Dougall M Norris, Olivia J Conway, Ming Yang, Christopher Gribben, Fatima Lutgu, James R Krycer, Richard J Mills, Ioannis Kamzolas, Conceição Pereira, Martin Dale, Amber S Shun-Shion, Harry JM Baird, James A Horscroft, Alice P Sowton, Marcella Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J Murray, David C Gershlick, James Edward Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J Fazakerley

Nature Genetics (2023)

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Alice Williamson, Dougall M Norris, Xianyong Yin, K Alaine Broadaway, Anne H Moxley, Swarooparani Vadlamudi, Emma P Wilson, Anne U Jackson, Vasudha Ahuja, Mette K Andersen...Stephen O’Rahilly, Daniel J Fazakerley, Claudia Langenberg

Biochemical Society Transactions (2023)

Insulin signalling and GLUT4 trafficking in insulin resistance

Julian van Gerwen, Amber S Shun-Shion, Daniel J Fazakerley

JCB (2023)

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

Conceição Pereira, Danièle Stalder, Georgina SF Anderson, Amber S Shun-Shion, Jack Houghton, Robin Antrobus, Michael A Chapman, Daniel J Fazakerley, David C Gershlick

Nat Commun (2023)

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

Daniel J Fazakerley, Julian van Gerwen, Kristen C Cooke, Xiaowen Duan, Elise J Needham, Søren Madsen, Dougall M Norris, Amber S Shun-Shion, James R Krycer, James G Burchfield, Pengyi Yang, Mark R Wade, Joseph T Brozinick, David E James, Sean J Humphrey

Life Science Alliance (2023)

A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology

Alexis Diaz-Vegas, Dougall M Norris, Sigrid Jall-Rogg, Kristen C Cooke, Olivia J Conway, Amber S Shun-Shion, Xiaowen Duan, Meg Potter, Julian van Gerwen, Harry JM Baird, Sean J Humphrey, David E James, Daniel J Fazakerley, James G Burchfield

Trends in Biochemical Sciences (2022)

Integrating adipocyte insulin signaling and metabolism in the multi-omics era 

C Martinez Calejman, WG Doxsey, DJ Fazakerley, DA Guertin

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Biochemical Journal (2022)

GLUT4 On the move

Daniel J Fazakerley, Francoise Koumanov, Geoffrey D Holman

Free Radic Biol Med (2022)

The role of mitochondrial reactive oxygen species in insulin resistance

Anita Ayer, Daniel J Fazakerley, David E James, Roland Stocker

Biochemical Journal (2022)

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Xiaowen Duan, Dougall M. Norris, Sean J. Humphrey, Pengyi Yang, Kristen C. Cooke, Will P. Bultitude, Benjamin L. Parker, Olivia J. Conway, James G. Burchfield, James R. Krycer, Frances M. Brodsky, David E. James, Daniel J. Fazakerley 

Redox Biology (2021)

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Anita Ayer, Daniel J Fazakerley, Cacang Suarna, Ghassan J Maghzal, Diba Sheipouri, Kevin J Lee, Michelle C Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY Kong, Jelske N van der Veen, Andrian Yang, Joshua WK Ho, Steven G Clarke, David E James, Ian W Dawes, Dennis E Vance, Catherine F Clarke, René L Jacobs, Roland Stocker

JBC (2020)

Insulin signaling requires glucose to promote lipid anabolism in adipocytes

James R Krycer, Lake-Ee Quek, Deanne Francis, Armella Zadoorian, Fiona C Weiss, Kristen C Cooke, Marin E Nelson, Alexis Diaz-Vegas, Sean J Humphrey, Richard Scalzo, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Kevin Huynh, Corey Giles, Bianca Varney, Shilpa R Nagarajan, Andrew J Hoy, Tomoyoshi Soga, Peter J Meikle, Gregory J Cooney, Daniel J Fazakerley, David E James